Peripheral 5-HT2-like receptors. Can they be classified with the available antagonists?
نویسندگان
چکیده
منابع مشابه
Participation of 5-HT1-Like Receptors and 5-HT2 Receptors in Serotonin-Induced Contraction of Human Isolated Coronary Arteries 5-HT1-Like Receptors Resemble Cloned 5-HT1Dp Receptors
Background Serotonin may contract human large coronary arteries through two 5-hydroxtryptamine (5-HT) receptors, 5-HT1-like and 5 -HT2. These 5-HT1-like receptors resemble both cloned 5-HT1D receptor subtypes, 5-HT'1D, and 5 -HT1Ds. Although these subtypes have similar pharmacology, 5-HT1Dg receptors appear to have lower affinity for ketanserin than 5-HT1Di receptors. We assessed the relative p...
متن کاملBlock of 5-HT2 Receptors Enhances Hippocampal Long-Term Potentiation
The effect of endogenous serotonin on long-term potentiation (LTP) in region CAI was studied by blocking 5-HT2 receptors with ketanserin in rat hippocampal slices. Such a block significantly en-hanced long-term potentiation of the CAI population spike induced by high frequency stimulation of the schaffer collateral/ commissural pathway. This implies that serotonin acts on 5-HT2 receptors in CAI...
متن کاملPhysiologically identified 5-HT2-like receptors at the crayfish neuromuscular junction.
The model synaptic preparation of the crayfish opener neuromuscular junction is known to be responsive to exogenous application of 5-HT. The primary effect of 5-HT is an enhancement of vesicular release from the presynaptic motor nerve terminal. 5-HT is known to act through an IP(3) cascade which suggests the presence of a 5-HT(2) receptor subtype; however, this is based on vertebrate 5-HT rece...
متن کاملVariable Participation of 5-HT1-Like Receptors and 5-HT2 Receptors in Serotonin-Induced Contraction of Human Isolated Coronary Arteries
Background Serotonin may contract human large coronary arteries through two 5-hydroxtryptamine (5-HT) receptors, 5-HT1-like and 5 -HT2. These 5-HT1-like receptors resemble both cloned 5-HT1D receptor subtypes, 5-HT'1D, and 5 -HT1Ds. Although these subtypes have similar pharmacology, 5-HT1Dg receptors appear to have lower affinity for ketanserin than 5-HT1Di receptors. We assessed the relative p...
متن کاملHow reliably can a material be classified as a nanomaterial? Available particle-sizing techniques at work
ABSTRACT Currently established and projected regulatory frameworks require the classification of materials (whether nano or non-nano) as specified by respective definitions, most of which are based on the size of the constituent particles. This brings up the question if currently available techniques for particle size determination are capable of reliably classifying materials that potentially ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1986
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1986.tb10239.x